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ORIGINAL ARTICLE
Year : 2018  |  Volume : 1  |  Issue : 4  |  Page : 234-238

Anti-cyclic citrullinated peptide antibodies in ulcerative colitis with and without joint involvement


1 GIT Unit, Mataria Teaching Hospital, Cairo, Egypt
2 Orthopaedic Surgery, Mataria Teaching Hospital, Cairo, Egypt
3 Clinical Pathology, NIUN, Cairo, Egypt
4 Rheumatology Department, Al Azhar University, Cairo, Egypt

Correspondence Address:
Tarek A Fouad
GIT Unit, Mataria Teaching Hospital, Mataria Square, Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JMISR.JMISR_82_18

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Background Joint affection is the most common extraintestinal manifestation of ulcerative colitis (UC). Despite the high specificity of anti-cyclic citrullinated peptide (CCP) antibodies for rheumatoid arthritis, their role in UC remains unclear. Aim The aims of this study were to assess the prevalence of anti-CCP antibodies in patients with UC and to investigate any association with joint affection. Patients and methods A total of 60 patients with UC were studied. Demographic data were collected, careful history was taken, and clinical examination including rheumatologic examination was done. A blood sample was collected for assessment of anti-CCP and other laboratory tests. Colonoscopy was done for assessment of severity and extension of UC. Results Joint affection was found in 28.33% of patients. Anti-CCP antibody was positive in 8.33% of patients. There were no statistically significant differences between patients with positive and negative anti-CCP antibody regarding joint affection or UC activity or extension. Conclusion The prevalence of anti-CCP antibodies in patients with UC was 8.33%, but there was no association between the presence of these antibodies and the joint affection or disease activity or extension.


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