ORIGINAL ARTICLE |
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Year : 2018 | Volume
: 1
| Issue : 4 | Page : 234-238 |
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Anti-cyclic citrullinated peptide antibodies in ulcerative colitis with and without joint involvement
Tarek A Fouad1, El Saied E Shabaan1, Mohamed A Safy2, Aisha El-Shimy3, Hala I Mohamed3, Wael Gomah4
1 GIT Unit, Mataria Teaching Hospital, Cairo, Egypt 2 Orthopaedic Surgery, Mataria Teaching Hospital, Cairo, Egypt 3 Clinical Pathology, NIUN, Cairo, Egypt 4 Rheumatology Department, Al Azhar University, Cairo, Egypt
Correspondence Address:
Tarek A Fouad GIT Unit, Mataria Teaching Hospital, Mataria Square, Cairo Egypt
Source of Support: None, Conflict of Interest: None | 3 |
DOI: 10.4103/JMISR.JMISR_82_18
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Background
Joint affection is the most common extraintestinal manifestation of ulcerative colitis (UC). Despite the high specificity of anti-cyclic citrullinated peptide (CCP) antibodies for rheumatoid arthritis, their role in UC remains unclear.
Aim
The aims of this study were to assess the prevalence of anti-CCP antibodies in patients with UC and to investigate any association with joint affection.
Patients and methods
A total of 60 patients with UC were studied. Demographic data were collected, careful history was taken, and clinical examination including rheumatologic examination was done. A blood sample was collected for assessment of anti-CCP and other laboratory tests. Colonoscopy was done for assessment of severity and extension of UC.
Results
Joint affection was found in 28.33% of patients. Anti-CCP antibody was positive in 8.33% of patients. There were no statistically significant differences between patients with positive and negative anti-CCP antibody regarding joint affection or UC activity or extension.
Conclusion
The prevalence of anti-CCP antibodies in patients with UC was 8.33%, but there was no association between the presence of these antibodies and the joint affection or disease activity or extension.
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